Description
Product Characteristics: bHLHb32 antibody, Cardiovascular helix loop helix factor 1 antibody, Cardiovascular helix-loop-helix factor 1 antibody, CHF1 antibody, Class B basic helix-loop-helix protein 32 antibody, GRIDLOCK antibody, GRL antibody, Hairy and enhancer of split related 2 antibody, Hairy and enhancer of split-related protein 2 antibody, Hairy related transcription factor 2 antibody, Hairy-related transcription factor 2 antibody, Hairy/enhancer-of-split related with YRPW motif protein 2 antibody, hCHF1 antibody, HERP antibody, HERP1 antibody, HES related repressor protein 1 antibody, HES-related repressor protein 2 antibody, HESR-2 antibody, HESR2 antibody, hey2 antibody, HEY2_HUMAN antibody, hHRT2 antibody, HRT-2 antibody, HRT2 antibody, MGC10720 antibody, Protein gridlock homolog antibody
Target Information: This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]